Cancer Research

Organ specific Cancer depends on the area of disease cells happen specifically organ. There are more than 200 different types of cancer diagnosed. Among them, Lung cancer, breast cancer is the most common cancer diagnosed in 2015. Apart from this prostate cancer, colon cancers, bladder cancer, breast cancer are the most common type cancer. The rare types of cancers are which affect the bone known as Bone Cancer. Depending upon the location of cancer the causes, symptoms, and method of treatments vary. Carcinoma, Sarcoma,  leukaemia, lymphoma, and melanoma are the types of cancer found in different organs.

Risk expectation and prediction and Cancer prevention, growth counteractive action is also promising and encouraging areas of Epigenetics. A high adequacy of demethylating agents were accounted for essentially in hematological malignancies in view of new conventions with low dose and long exposure, and their utilization is presently being striven for strong tumors. During the cell’s transformation to Cancerous cell, Epigenetic modifications are also more important like genetic mutation. Their manipulation brings a great promising approach for inventing, detecting and treatment of cancer.

Cancer Bioinformatics is another interdisciplinary region including organic, measurable and computational sciences. Now a day’s bioinformatics innovation is for the most part utilized for the special growth investigation. Ribosomal S6 protein kinase 4 (RSK4) is a vital novel tumor silencer that hinders breast cancer cell development and initiates senescence. Utilizing pair proclivity cleaning, we got protein buildings that associated with RSK4 or RSK4m. Mass range examination was performed to distinguish the acquired protein edifices, and bioinformatics investigation was performed.

Radiation therapy occurs in the presence of biochemical recurrence after prostatectomy to assess whether this results in shifts of histopathological prognostic factors such as the Gleason Score using ionizing radiation  in the treatment of cancer. The field of radiation oncology covers the integration of radiation therapy into multimodal treatment approaches. Radiation Oncology provides an open access forum for researchers and clinicians involved in the management and treatment of cancer patients, bringing together the latest research and advances in the field. 

Tumor Invasion and Metastasis theme of the Department of Cancer Biology aim to expand translational research on the processes that enable tumor cells to invade surrounding tissues, disseminate through the body and colonize distant organs. Metastasis is responsible for the majority of cancer-associated deaths. By developing treatment approaches that target invasion and metastasis, we aim to significantly reduce cancer mortality. This is a largely unexplored area for the development of novel therapeutic drugs because the molecular mechanisms that mediate cancer invasion and metastasis are still poorly understood.

Nanotechnologies are also being investigated to deliver immunotherapy. Standalone nanoparticle vaccines are also being designed to raise sufficient T cell response to eradicate tumors, through co-delivery of antigen and adjuvant, the inclusion of multiple antigens to stimulate multiple dendritic cell targets, and continuous release of antigens for prolonged immune stimulation. Molecular blockers of immune-suppressive factors produced can also be co-encapsulated in nanoparticle vaccines to alter the immune context of tumors and improve response, an approach being pursued in the Nano Approaches to Modulate Host Cell Response for Cancer Therapy Center at UNC.

 Gastricepithelium is continuously regenerated by gastric stem cells, which give rise to various kinds of daughter cells, including parietal cells, chief cells, surface mucous cells, mucous neck cells, and enter endocrine cells. Recently, it was hypothesized that cancer stem cells drive the cancer growth and metastasis. In contrast to conventional clonal evolution hypothesis, only cancer stem cells can initiate tumor formation, self-renew, and differentiate into various kinds of daughter cells. we review here how critical signaling pathways, including hedgehog, Want, Notch, epidermal growth factor, and bone morphogenetic protein signaling, may regulate the self-renewal and differentiation of gastric stem cells and gastric cancer stem cells.

 Biomarkers have a particularly high top side for therapeutic interventions in cancer patients. Most cancer biomarkers contains proteins or altered segments of deoxyribonucleic acid, and area unit expressed altogether cells, simply at higher rates in cancer cells.These growth biomarkers are accustomed track the health of tumors, however cannot function the only real diagnostic for specific cancers. Samples of tumoral markers accustomed follow up cancer treatment are the Carcinoembryonic antigen (CEA) for large intestine cancer and therefore the Prostate Specific antigen (PSA) for glandular cancer. In 2014, Cancer analysis known current growth Cells  and current growth DNA as metastasizing growth biomarkers with special cellular differentiation and prognostic skills.